SF1126
SF1126 is a first-in-class, pan and dual PI3K/BRD4 inhibitor developed as an RGDS-conjugated prodrug of LY294002. This design enhances solubility and promotes tumor-targeted delivery via integrin binding. It has demonstrated activity in both in vitro and in vivo cancer models, including studies in multiple myeloma and solid tumors.
Product Specifications
CAS Number
936487-67-1
Field of Research
Cell Biology, Signal Transduction
Smiles
C (OC (CCC (N[C@H] (C (NCC (N[C@H] (C (N[C@H] (C (O) =O) CO) =O) CC ([O-]) =O) =O) =O) CCCNC (=N) N) =O) =O) [N+]1 (CCOCC1) C=2OC3=C (C=CC=C3C (=O) C2) C4=CC=CC=C4
Molecular Formula
C39H48N8O14
Molecular Weight
852.84
Storage Conditions
-20°C
Notes
For research use only.
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