Tefinostat
Tefinostat (CHR-2845) is a selective HDAC inhibitor activated intracellularly by human carboxylesterase-1 (hCE-1) to CHR-2847, targeting monocytes and macrophages. Its antitumor activity is under investigation for leukemia and hematologic malignancies, supported by in vitro and in vivo research models.
Product Specifications
CAS Number
914382-60-8
Product Name Alternative
CHR 2845, CHR2845, CHR-2845, HDAC, Tefinostat
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Purity
99.41% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.66 mM) ; DMSO:90 mg/mL (181.59 mM)
Smiles
ONC (=O) CCCCCCC (=O) Nc1ccc (CN[C@H] (C (=O) OC2CCCC2) c2ccccc2) cc1
Molecular Formula
C28H37N3O5
Molecular Weight
495.61
Storage Conditions
-20°C
Notes
For research use only.
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