TIK-301

TIK-301 is an orally bioavailable, chlorinated melatonin analog functioning as a potent agonist at MT1 and MT2 receptors (Ki values 0.081 nM and 0.042 nM) and an antagonist at 5-HT2B/2C receptors. Its pharmacological profile supports research into circadian rhythm and sleep disorders, as well as depression, with applications in both in vitro binding assays and in vivo behavioral studies.