Zotatifin
Zotatifin (eFT226) is a potent and selective inhibitor of eukaryotic initiation factor 4A (eIF4A) with demonstrated antiviral and anticancer properties. It suppresses tumor growth in preclinical models by targeting oncogenic signaling pathways, such as those driven by receptor tyrosine kinases, and induces apoptosis through inhibition of specific oncoprotein synthesis like Sox4. Its activity has been validated in both in vitro and in vivo research studies.
Product Specifications
CAS Number
2098191-53-6
Product Name Alternative
EFT 226, eFT226, eFT-226, eIF4A, Zotatifin
Field of Research
Cell Biology, Immunology & Inflammation, Infectious Disease & Virology
Purity
98.85% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.26 mM) ; DMSO:180 mg/mL (369.19 mM)
Smiles
O[C@]12[C@] ([C@@H] ([C@@H] (CN (C) C) [C@H]1O) C3=CC=CC=C3) (OC=4C2=C (OC) N=C (OC) C4) C5=CC=C (C#N) C=C5
Molecular Formula
C28H29N3O5
Molecular Weight
487.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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