CL2A-SN-38

CL2A-SN-38 is a linker-payload conjugate designed for constructing Antibody-Drug Conjugates (ADCs) . It facilitates the targeted delivery of the potent topoisomerase I inhibitor SN-38 to tumor cells. This compound is widely used in ADC research for evaluating efficacy in both in vitro cytotoxicity assays and in vivo xenograft models.

Product Specifications

CAS Number

1279680-68-0

Product Name Alternative

ADC, ADC linker, Camptothecins, bystander effect, antitumor, DrugLinkerConjugatesforADC, Drug-Linker Conjugates for ADC, DNA Topoisomerase I, DrugLinker Conjugates for ADC, CL2A-SN-38, CL2A-SN38, CL2ASN38, CL-2A-SN-38, CL2A, CL2A SN 38, inhibit, Inhibitor, SN-38

Purity

95.00% (May vary between batches)

Solubility

DMSO:80 mg/mL (54.03 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (2.23 mM)

Smiles

CCc1c2Cn3c (cc4c (COC (=O) [C@@]4 (CC) OC (=O) OCc4ccc (NC (=O) [C@H] (CCCCN) NC (=O) COCC (=O) NCCOCCOCCOCCOCCOCCOCCOCCOCCn5cc (CNC (=O) C6CCC (CN7C (=O) C=CC7=O) CC6) nn5) cc4) c3=O) -c2nc2ccc (O) cc12