PLX647
PLX647 is a potent and selective small molecule inhibitor targeting the FMS (CSF1R) and KIT receptor tyrosine kinases, with IC50 values of 28 nM and 16 nM, respectively. It is utilized in preclinical research to investigate the roles of these kinases in oncology, inflammatory diseases, and neurobiology through both in vitro and in vivo experimental models.
Product Specifications
CAS Number
873786-09-5
Product Name Alternative
C-Kit, cKit, colony stimulating factor 1 receptor, CD117, c-Fms, cFms, cells, CSF1R, CSF-1 receptor, CSF-1R, differentiation, BCR-FMS, BCR-KIT, bone, PLX 647, PLX-647, PLX647, osteoclast, inhibit, Inhibitor, proliferation, SCFR
Field of Research
Signal Transduction
Purity
99.38% (May vary between batches)
Solubility
DMSO:31 mg/mL (81.07 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.23 mM)
Smiles
FC (F) (F) c1ccc (CNc2ccc (Cc3c[nH]c4ncccc34) cn2) cc1
Molecular Formula
C21H17F3N4
Molecular Weight
382.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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