PF-06273340
PF-06273340 is a potent, selective, and peripherally restricted pan-Trk inhibitor with single-digit nM IC50 values against TrkA, TrkB, and TrkC. Its pharmacokinetic profile, characterized by low hepatic metabolism, active efflux transport, and moderate permeability, supports its utility in preclinical research for investigating peripheral Trk-mediated pathways in pain and oncology models.
Product Specifications
CAS Number
1402438-74-7
Product Name Alternative
PF 6273340, PF 06273340, PF06273340, PF-06273340, PF6273340, PF-6273340, Trkreceptor, Tropomyosin related kinase receptor, Trk Receptor, Trk receptor, TrkC, TrkB, TrkA, inhibit, Inhibitor
Field of Research
Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
Ethanol:1 mg/mL (2.08 mM) ; DMSO:90 mg/mL (187.53 mM) ; H2O:Insoluble
Smiles
C (=O) (C=1C=2C (N (C (CO) (C) C) C1) =NC (N) =NC2) C=3C=C (NC (CC4=CC=C (Cl) C=N4) =O) C=NC3
Molecular Formula
C23H22ClN7O3
Molecular Weight
479.92
Storage Conditions
-20°C
Notes
For research use only.
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