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C5aR1 antagonist 1

C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC50 values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases[1].

Product Specifications

CAS Number

2365325-67-1

UNSPSC

12352005

Target

Complement System

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/c5ar1-antagonist-1.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=C(CN1C4CCN(CC4)C5=C(C)C=CC=C5F)C=CC=C3

Molecular Formula

C28H27F4N3O

Molecular Weight

497.53

References & Citations

[1]Hubler, F., D. Renneberg, et al. "Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity." Journal of Medicinal Chemistry. 2024 March 04.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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