C5aR1 antagonist 1
Product Specifications
UNSPSC Description
C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC50 values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases[1].
Target Antigen
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/c5ar1-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=C(CN1C4CCN(CC4)C5=C(C)C=CC=C5F)C=CC=C3
Molecular Weight
497.53
References & Citations
[1]Hubler, F., D. Renneberg, et al. "Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity." Journal of Medicinal Chemistry. 2024 March 04.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163378/C5aR1-antagonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163378/
Clinical Information
No Development Reported
CAS Number
2365325-67-1
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