Imipramine

Imipramine is an orally active Fascin1 inhibitor with antidepressant properties that also exhibits antitumor activity. It functions as a potent serotonin transporter blocker (IC50: 32 nM) and induces apoptosis and autophagy in glioma cells. Its neuroprotective and immunomodulatory effects, including inhibition of tumor cell invasion, make it a valuable research tool for studying cancers like glioblastoma and breast cancer, as well as neurological disorders.