10-Formyldihydrofolate
This metabolite of the anticancer agent methotrexate acts as a dual inhibitor of thymidylate synthase and GAR transformylase, enzymes critical for nucleotide synthesis. It is consequently a valuable tool for in vitro studies in oncology and biochemistry research, particularly for investigating antifolate mechanisms.
Product Specifications
CAS Number
28459-40-7
Field of Research
Metabolism Research
Smiles
O=C1C2=C (NCC (CN (C=O) C3=CC=C (C (N[C@@H] (CCC (O) =O) C (O) =O) =O) C=C3) =N2) NC (N) =N1
Molecular Formula
C20H21N7O7
Molecular Weight
471.43
Storage Conditions
-20°C
Notes
For research use only.
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