NS-638
NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties. K+-stimulated intracellular Ca2+-elevation is blocked with an IC50 value of 3.4 μM.
Product Specifications
CAS Number
[150493-34-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/NS-638.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : ≥ 34 mg/mL
Smiles
NC1=NC2=CC(C(F)(F)F)=CC=C2N1CC3=CC=C(Cl)C=C3
Molecular Formula
C15H11ClF3N3
Molecular Weight
325.72
Precautions
H315, H319, H335
References & Citations
[1]M?ller A, et al. Pharmacological profile and anti-ischemic properties of the Ca (2+) -channel blocker NS-638. Neurol Res. 1995 Oct;17 (5) :353-60.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel
Available Sizes
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