Sivelestat sodium tetrahydrate
Sivelestat sodium tetrahydrate (ONO-5046) is a potent and competitive inhibitor of human neutrophil elastase, exhibiting an IC50 of 44 nM and a Ki of 200 nM. This compound is a research tool for investigating conditions such as acute lung injury and ARDS, including in the context of COVID-19, with applications in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
201677-61-4
Product Name Alternative
Elaspol, Elaspol sodium, Elaspol sodium tetrahydrate, Elaspol sodium Tetrahydrate, ONO 5046, ONO5046 sodium, ONO-5046 sodium, ONO5046 sodium tetrahydrate, ONO5046 sodium Tetrahydrate, ONO-5046 sodium tetrahydrate, ONO-5046 sodium Tetrahydrate, ONO5046, ONO-5046, Neutrophil elastase (human), Serine Protease, SerineProtease, Sivelestat Sodium, Sivelestat sodium, Sivelestat Sodium Hydrate, Sivelestat sodium Tetrahydrate
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
99.64% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.46 mM) ; DMSO:225 mg/mL (425.73 mM)
Smiles
O.O.O.O.[NaH].CC (C) (C) C (=O) Oc1ccc (cc1) S (=O) (=O) Nc1ccccc1C (=O) NCC (O) =O
Molecular Formula
C20H29N2NaO11S
Molecular Weight
528.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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