Mavelertinib
Mavelertinib (PF-06747775) is a potent, orally bioavailable, and selective EGFR tyrosine kinase inhibitor targeting oncogenic mutants including T790M/L858R and T790M/Del. It is a research tool for investigating non-small cell lung cancer (NSCLC), with demonstrated activity in both cellular assays and in vivo xenograft models.
Product Specifications
CAS Number
1776112-90-3
Product Name Alternative
PFE-X775, PF6747775, PF-6747775, PF-7775, PF06747775, PF-06747775, PF 6747775, PF 06747775, EGFR (T790M/L858R), Mavelertinib
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.89% (May vary between batches)
Solubility
H2O:<0.1 mg/mL; DMSO:30 mg/mL (72.22 mM)
Smiles
COc1nn (C) cc1Nc1nc (nc2n (C) cnc12) N1C[C@@H] (F) [C@@H] (C1) NC (=O) C=C
Molecular Formula
C18H22FN9O2
Molecular Weight
415.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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