U0126
U0126 is a potent, selective, and non-competitive MEK1/2 inhibitor with IC50 values of 0.07 and 0.06 μM, respectively. It effectively suppresses MAPK signaling and is widely used in vitro and in vivo to study cellular processes, including its documented role in inhibiting autophagy and mitophagy.
Product Specifications
CAS Number
109511-58-2
Product Name Alternative
U 0126, U0126, U-0126, Autophagy, Mitochondrial Autophagy, Mitogen-activated protein kinase kinase, Mitophagy, inhibit, Influenza Virus, MEK, MEK1, MEK2, MAP2K, MAPKK, Inhibitor
Field of Research
Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
MEK1 and MEK2 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 200 mg/ml) .
Smiles
N#CC (=C (SC=1C=CC=CC1N) N) C (C#N) =C (SC=2C=CC=CC2N) N
Molecular Formula
C18H16N6S2
Molecular Weight
380.49
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Available Sizes
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