DM1-SMe
DM1-SMe (DM1-SSMe) is a highly potent maytansinoid microtubule inhibitor, demonstrating 3-10 times greater potency than Maytansine with IC50 values ranging from 0.003 to 0.01 nM in human tumor cell lines. This small molecule is a valuable research tool for investigating tubulin-targeting agents in both in vitro cytotoxicity assays and in vivo preclinical cancer models.
Product Specifications
CAS Number
138148-68-2
Product Name Alternative
Tumor cell, ADC Payload, ADCCytotoxin, ADC Cytotoxin, antibody-drug conjugate, anti-tumor activity, DM1 SMe, DM1SMe, DM-1-SMe, DM1-SMe, DM1-SSMe, inhibit, Microtubule Associated, microtubule, Microtubule/Tubulin, MicrotubuleAssociated, maytansinoid, Inhibitor
Field of Research
Signal Transduction
Purity
96.00% (May vary between batches)
Solubility
DMSO:60 mg/mL (76.49 mM) ; H2O:Insoluble;10% DMSO+90% Corn Oil:2.5 mg/mL (3.19 mM)
Smiles
[H][C@@]12O[C@@]1 (C) [C@H] (CC (=O) N (C) c1cc (C\C (C) =C/C=C\[C@@H] (OC) [C@@]3 (O) C[C@] ([H]) (OC (=O) N3) [C@H]2C) cc (OC) c1Cl) OC (=O) [C@H] (C) N (C) C (=O) CCSSC
Molecular Formula
C36H50ClN3O10S2
Molecular Weight
784.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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