KRCA-0008
KRCA-0008 is a selective ALK/Ack1 inhibitor with IC50s of 12 and 4 nM for ALK and Ack1, respectively. KRCA-0008 can be used for the research of cancer[1][2].
Product Specifications
CAS Number
1472795-20-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ack1; Anaplastic lymphoma kinase (ALK) ; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KRCA-0008.html
Purity
96.72
Solubility
DMSO : 230 mg/mL (ultrasonic)
Smiles
ClC1=CN=C(NC2=CC=C(N3CCN(C(C)=O)CC3)C=C2OC)N=C1NC4=CC=C(N5CCN(C(C)=O)CC5)C=C4OC
Molecular Formula
C30H37ClN8O4
Molecular Weight
609.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Park CH, et al. Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment. Bioorg Med Chem Lett. 2013 Nov 15;23 (22) :6192-6.|[2]Hwang J, et al. KRCA-0008 suppresses ALK-positive anaplastic large-cell lymphoma growth. Invest New Drugs. 2020 Oct;38 (5) :1282-1291.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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