CCT018159
CCT018159 is a 3,4-diarylpyrazole resorcinol-based, ATP-competitive HSP90 inhibitor with IC50 values of 3.2 μM (human Hsp90β) and 6.6 μM (yeast Hsp90) . It suppresses tumor angiogenesis and invasion by inhibiting key endothelial and tumor cell functions, leading to G1 cell cycle arrest and apoptosis in vitro.
Product Specifications
CAS Number
171009-07-7
Product Name Alternative
CCT018159, CCT-018159, CCT 018159, apoptosis, HSP90
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Purity
98.78% (May vary between batches)
Solubility
DMSO:112.5 mg/mL (319.26 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.35 mM)
Smiles
CC1=C (C (=NN1) C2=CC (CC) =C (O) C=C2O) C=3C=C4C (=CC3) OCCO4
Molecular Formula
C20H20N2O4
Molecular Weight
352.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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