Eggmanone
Eggmanone (EGM1) is a potent and selective PDE4D3 antagonist (IC50 = 72 nM) with 40-50-fold selectivity over other PDEs. Its mechanism involves PDE4 inhibition, leading to PKA activation and subsequent blockade of the Hedgehog signaling pathway, making it a valuable research tool for studying Hh-related cancers and developmental disorders in vitro.
Product Specifications
CAS Number
505068-32-6
Field of Research
Metabolism Research
Smiles
CC (=C) Cn1c (SCC (=O) c2cccs2) nc2sc3CCCCc3c2c1=O
Molecular Formula
C20H20N2O2S3
Molecular Weight
416.58
Storage Conditions
-20°C
Notes
For research use only.
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