Dasatinib hydrochloride
Dasatinib hydrochloride is a potent, orally bioavailable dual inhibitor of Src and Bcr-Abl tyrosine kinases, with sub-nanomolar IC50 values. It induces apoptosis and autophagy and is widely used in cancer research, including in vitro studies of leukemia cell lines and in vivo xenograft models for investigating therapeutic mechanisms.
Product Specifications
CAS Number
854001-07-3
Product Name Alternative
Src, BcrAbl, BMS-354825 HCl, Abl, Dasatinib Hydrochloride, c-Kit (D816V), c-Kit (wt), cKit
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.88% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.77 mM) ; DMSO:13.5 mg/mL (25.74 mM)
Smiles
Cl.Cc1nc (Nc2ncc (s2) C (=O) Nc2c (C) cccc2Cl) cc (n1) N1CCN (CCO) CC1
Molecular Formula
C22H27Cl2N7O2S
Molecular Weight
524.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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