PNU-282987 S enantiomer hydrochloride

(S) -PNU-282987 is the enantiomerically pure form of a potent and selective α7 nicotinic acetylcholine receptor agonist (Ki = 26 nM) . It exhibits negligible activity at other major nAChR subtypes and neurotransmitter receptors, except for moderate 5-HT3 receptor affinity. This selectivity makes it a valuable research tool for investigating α7 nAChR function in neuropsychiatric and neurodegenerative disease models, both in vitro and in vivo.