S107 hydrochloride

S107 hydrochloride is a RyR-selective 1,4-benzothiazepine derivative that stabilizes the RyR2 channel by increasing the binding affinity of calstabin2. This action is particularly relevant for studying mutant or PKA-phosphorylated channels in cardiovascular research, with applications in both in vitro and in vivo models of conditions like catecholaminergic polymorphic ventricular tachycardia (CPVT) .