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(±) -AMG 487

AMG 487 is a potent and selective CXCR3 antagonist, effectively inhibiting IP-10, ITAC, and MIG-induced chemotaxis with IC50 values of 8, 15, and 36 nM, respectively. This small molecule is a valuable research tool for studying CXCR3 function in autoimmune diseases, transplant rejection, and cancer in both cellular and animal models.

Product Specifications

Field of Research

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Smiles

CCOC1=CC=C (N2C (C (N (C (CC3=CC=C (OC (F) (F) F) C=C3) =O) CC4=CN=CC=C4) C) =NC5=C (C2=O) C=CC=N5) C=C1

Molecular Formula

C32H28F3N5O4

Molecular Weight

603.59

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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