AD57 (hydrochloride)
AD57 is a polypharmacological small molecule that potently inhibits the RET tyrosine kinase (IC50: 2 nM) and disrupts downstream effectors like Raf and Src. This multi-target action suppresses oncogenic signaling pathways, making it a useful research tool for studying RET-driven cancers such as medullary thyroid carcinoma in both cellular and animal models.
Product Specifications
CAS Number
2320261-72-9
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
Cl.CC (C) n1nc (-c2ccc (NC (=O) Nc3cccc (c3) C (F) (F) F) cc2) c2c (N) ncnc12
Molecular Formula
C22H21ClF3N7O
Molecular Weight
491.9
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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