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AD57 (hydrochloride)

AD57 is a polypharmacological small molecule that potently inhibits the RET tyrosine kinase (IC50: 2 nM) and disrupts downstream effectors like Raf and Src. This multi-target action suppresses oncogenic signaling pathways, making it a useful research tool for studying RET-driven cancers such as medullary thyroid carcinoma in both cellular and animal models.

Product Specifications

CAS Number

2320261-72-9

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Smiles

Cl.CC (C) n1nc (-c2ccc (NC (=O) Nc3cccc (c3) C (F) (F) F) cc2) c2c (N) ncnc12

Molecular Formula

C22H21ClF3N7O

Molecular Weight

491.9

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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