Adaphostin
Adaphostin (NSC-680410) is a small molecule inhibitor targeting the p210Bcr-Abl tyrosine kinase, exhibiting an IC50 of 14 μM. It has been utilized in research to study chronic myeloid leukemia (CML), demonstrating cytotoxic effects in vitro and showing antitumor activity in preclinical in vivo models.
Product Specifications
CAS Number
241127-58-2
Product Name Alternative
P210Bcr/abl, ROS, tyrosine kinase, 1-Adamantyl 4- ((2,5-Dihydroxybenzyl) Amino) Benzoate, Adaphostin, Apoptosis, Bcr-Abl, BcrAbl, chronic myelogenous leukemia, CML, Inhibitor, inhibit, myeloid, NSC 680410, NSC680410, NSC-680410
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
97.31% (May vary between batches)
Solubility
DMSO:55 mg/mL (139.78 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.08 mM) ; Ethanol:< 40 mg/mL (101.66 mM)
Smiles
Oc1ccc (O) c (CNc2ccc (cc2) C (=O) OC23CC4CC (CC (C4) C2) C3) c1
Molecular Formula
C24H27NO4
Molecular Weight
393.48
Storage Conditions
-20°C
Notes
For research use only.
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