Pentostatin

Pentostatin (CI-825; Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase with Ki of 2.5 pM.

Product Specifications

CAS Number

[53910-25-1]

Product Name Alternative

CI-825; Deoxycoformycin

UNSPSC

12352005

Hazard Statement

H301

Target

Adenosine Deaminase; Antibiotic

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Pentostatin.html

Purity

99.93

Solubility

DMSO : ≥ 50 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1C(N=CN2[C@H](O[C@@H]3CO)C[C@@H]3O)=C2NC=NC1

Molecular Formula

C11H16N4O4

Molecular Weight

268.27

Precautions

H301

References & Citations

[1]Bethge WA, et al. Extracorporeal photopheresis combined with pentostatin in the conditioning regimen for canine hematopoietic cell transplantation does not prevent GVHD. Bone Marrow Transplant. 2014 Sep;49 (9) :1198-204.|[2]Dalla Rosa L, et al. Cordycepin (3'-deoxyadenosine) pentostatin (deoxycoformycin) combination treatment of mice experimentally infected with Trypanosoma evansi. Parasitology. 2013 Apr;140 (5) :663-71.