Pentostatin
Pentostatin (CI-825; Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase with Ki of 2.5 pM.
Product Specifications
CAS Number
53910-25-1
Product Name Alternative
CI-825; Deoxycoformycin
UNSPSC
12352005
Hazard Statement
H301
Target
Adenosine Deaminase; Antibiotic
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pentostatin.html
Purity
99.93
Solubility
DMSO : ≥ 50 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1C(N=CN2[C@H](O[C@@H]3CO)C[C@@H]3O)=C2NC=NC1
Molecular Formula
C11H16N4O4
Molecular Weight
268.27
Precautions
H301
References & Citations
[1]Bethge WA, et al. Extracorporeal photopheresis combined with pentostatin in the conditioning regimen for canine hematopoietic cell transplantation does not prevent GVHD. Bone Marrow Transplant. 2014 Sep;49 (9) :1198-204.|[2]Dalla Rosa L, et al. Cordycepin (3'-deoxyadenosine) pentostatin (deoxycoformycin) combination treatment of mice experimentally infected with Trypanosoma evansi. Parasitology. 2013 Apr;140 (5) :663-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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