Dolastatin 10 trifluoroacetate
Dolastatin 10 TFA is a marine-derived antimitotic agent that potently inhibits tubulin polymerization and non-competitively blocks vincristine binding. It is widely used in cancer research, demonstrating potent antitumor activity in both in vitro cytotoxicity assays and in vivo xenograft models.
Product Specifications
Smiles
CC[C@] ([C@@] (N (C ([C@] (/N=C (O) /[C@] (N (C) C) ([H]) C (C) C) ([H]) C (C) C) =O) C) ([H]) [C@@] (OC) ([H]) CC (N1CCC[C@@]1 ([H]) [C@@] (OC) ([H]) [C@@] (/C (O) =N/[C@@] (C2=NC=CS2) ([H]) CC3=CC=CC=C3) ([H]) C) =O) ([H]) C.FC (F) (C (O) =O) F
Molecular Formula
C44H69F3N6O8S
Molecular Weight
899.11
Storage Conditions
-20°C
Notes
For research use only.
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