Pruvanserin hydrochloride
Pruvanserin hydrochloride is a potent and selective inverse agonist of the 5-HT2A receptor, demonstrating high affinity in vitro with IC50 values of 0.35 nM (human) and 1 nM (rat) . Its functional activity, shown by inhibiting GTPγS accumulation, supports research in neuropsychiatric disorders such as schizophrenia, Parkinson's disease, and insomnia, with in vivo evidence of efficacy in rodent models of diabetic neuropathic pain.
Product Specifications
CAS Number
443144-27-2
Product Name Alternative
LY 2422347 hydrochloride, LY2422347 hydrochloride, EMD281014 hydrochloride, EMD281014 Hydrochloride, EMD-281014 Hydrochloride, EMD 281014 Hydrochloride, EMD 281014 hydrochloride
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.60% (May vary between batches)
Solubility
Ethanol:< 8 mg/mL; DMSO:< 32 mg/mL
Smiles
Cl.N#CC1=CNC2=C1C=CC=C2C (=O) N3CCN (CCC4=CC=C (F) C=C4) CC3
Molecular Formula
C22H22ClFN4O
Molecular Weight
412.89
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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