GW 583340 dihydrochloride
GW 583340 dihydrochloride is an orally active dual inhibitor of EGFR and ErbB2 tyrosine kinases. It reverses multidrug resistance mediated by ABCG2 and ABCB1 transporters, demonstrating potent in vitro activity against overexpressing tumor cells and significant in vivo efficacy in xenograft models.
Product Specifications
CAS Number
1173023-85-2
Product Name Alternative
GW583340, GW-583340, GW583340 dihydrochloride, GW-583340 Dihydrochloride, GW 583340, GW 583340 Dihydrochloride
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.80% (May vary between batches)
Solubility
DMSO:40 mg/mL (59.61 mM)
Smiles
O=S (C) (CCNCC1=NC (C2=CC3=C (NC4=CC=C (C (Cl) =C4) OCC5=CC (F) =CC=C5) N=CN=C3C=C2) =CS1) =O.Cl.Cl
Molecular Formula
C28H27Cl3FN5O3S2
Molecular Weight
671.03
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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