LY2606368 HCl (1234015-52-1 free base)

LY2606368 HCl is a potent and selective ATP-competitive inhibitor of checkpoint kinase 1 (Chk1), demonstrating an IC50 of 1.5 nM in SW1990 cells. This small molecule is a valuable research tool for studying DNA damage response pathways and has been utilized in both in vitro and in vivo cancer research models to investigate chemosensitization and targeted therapy.