M-Coumaric acid

M-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant. m-Coumaric acid is a BBB-penetrant metabolite of chlorogenic acid. m-Coumaric acid stimulates the cerebral nerves in vitro. m-Coumaric acid can evoke neurite outgrowth in hippocampal neuronal cells. m-Coumaric acid can promote neuronal differentiation. m-Coumaric acid increases spontaneous locomotor activity in mice by acting on the central nervous system. m-Coumaric acid inhibits the oxidation of L-dopa by epidermis tyrosinase. m-Coumaric acid attenuates non-catalytic protein glycosylation in retinas of diabetic rats[1][2][3].

Product Specifications

CAS Number

[588-30-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/m-Coumaric_acid.html

Purity

99.96

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C/C1=CC=CC(O)=C1

Molecular Formula

C9H8O3

Molecular Weight

164.16

Precautions

H315, H319, H335

References & Citations

[1]Ito H, et al. Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells. Biosci Biotechnol Biochem. 2008 Mar;72 (3) :885-8.|[2]Cabanes, J., et al., (1984) . Kinetic study on the slow inhibition of epidermis tyrosinase by m-coumaric acid. Biochimica et biophysica acta, 790 (2), 101–107. |[3]Moselhy Said Salama, et al., m-Coumaric acid attenuates non-catalytic protein glycosylation in the retinas of diabetic rats. Journal of Pesticide Science. Online ISSN : 1349-0923. ISSN-L : 0385-1559.