ML289
ML289 (VU0463597) is a brain-penetrant, selective negative allosteric modulator of the mGlu3 receptor with an IC50 of 0.66 μM. It exhibits >15-fold selectivity over mGlu2 and is inactive at mGlu5. This tool compound is useful for investigating mGlu3's role in CNS disorders in both cellular and animal models.
Product Specifications
CAS Number
1382481-79-9
Product Name Alternative
VU 0463597, VU0463597, VU-0463597, ML289, ML-289, ML 289, mGluR3
Field of Research
Neuroscience
Purity
99.09% (May vary between batches)
Solubility
DMSO:225 mg/mL (643.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.31 mM)
Smiles
COc1ccc (cc1) C#Cc1ccc (cc1) C (=O) N1CCC[C@@H] (CO) C1
Molecular Formula
C22H23NO3
Molecular Weight
349.42
Storage Conditions
-20°C
Notes
For research use only.
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