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PPY A

PPY A is a potent small molecule inhibitor effective against both wild-type and T315I mutant forms of Abl kinase, with IC50 values of 20 nM and 9 nM, respectively. It suppresses the proliferation of cells transformed by Bcr-Abl, making it a valuable tool for in vitro studies of drug-resistant chronic myeloid leukemia.

Product Specifications

CAS Number

875634-01-8

Product Name Alternative

PPY A, BcrAbl, Bcr-Abl1

Field of Research

Cardiovascular Research, Signal Transduction

Purity

98.22% (May vary between batches)

Solubility

DMSO:10 mg/mL (26.85 mM)

Smiles

O=C (C1=CN=CC (=C1) C2=CN=C3NC=C (C=4C=CC=CC4OC) C3=C2) N (C) C

Molecular Formula

C22H20N4O2

Molecular Weight

372.42

Storage Conditions

-20°C

Notes

For research use only.

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