KW-2449
KW-2449 is a potent and selective small molecule inhibitor primarily targeting Flt3 (IC50 = 6.6 nM), with additional modest activity against Bcr-Abl, FGFR1, and Aurora A kinases. It has been utilized in preclinical research to investigate acute myeloid leukemia (AML) mechanisms and therapeutic strategies in both cellular and animal models.
Product Specifications
CAS Number
1000669-72-6
Product Name Alternative
Src, Abl, Abl (T315I), Apoptosis, AuroraKinase, Aurora A, Aurora Kinase, BcrAbl, Bcr-Abl, cKit, Cluster of differentiation antigen 135, CD135, JAK2, inhibit, KW 2449, KW2449, KW-2449, Kit, FLT3 (D835Y), FLT3, Fms like tyrosine kinase 3, FGFR, FGFR1, Fibroblast growth factor receptor, Inhibitor
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.43% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:55 mg/mL (165.46 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.02 mM) ; Ethanol:62 mg/mL (186.52 mM)
Smiles
O=C (N1CCNCC1) c1ccc (C=Cc2n[nH]c3ccccc23) cc1
Molecular Formula
C20H20N4O
Molecular Weight
332.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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