Y134
Y134 is a potent, orally bioavailable, and selective estrogen receptor (ER) antagonist, exhibiting over 120-fold greater affinity for ERα (Ki=0.09 nM) than ERβ. It effectively blocks estrogen-stimulated proliferation of ER-positive breast cancer cells in vitro, making it a valuable research tool for studying ERα-driven oncology and endocrine pathways.
Product Specifications
CAS Number
849662-80-2
Product Name Alternative
Y 134, Y-134, Y134, estrogen receptor, Estrogen Receptor, EstrogenReceptor, ERR
Field of Research
Metabolism Research
Purity
99.72% (May vary between batches)
Solubility
DMSO:47.26 mg/mL (100 mM) ; Ethanol:47.26 mg/mL (100 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.23 mM)
Smiles
C (=O) (C1=C (SC=2C1=CC=C (O) C2) C3=CC=C (O) C=C3) C4=CC=C (C=C4) N5CCN (C (C) C) CC5
Molecular Formula
C28H28N2O3S
Molecular Weight
472.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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