Afeletecan free base
Afeletecan is a water-soluble camptothecin analog that acts as a topoisomerase I inhibitor by stabilizing the enzyme-DNA complex, leading to replication fork arrest, DNA double-strand breaks, and apoptosis. It is utilized in cancer research for investigating antitumor mechanisms in both cellular and animal models.
Product Specifications
CAS Number
215604-75-4
Smiles
O (C ([C@@H] (NC ([C@H] (CC1=CN=CN1) NC (NC2=CC=C (O[C@@H]3[C@@H] (O) [C@H] (OC) [C@H] (O) [C@H] (C) O3) C=C2) =S) =O) C (C) C) =O) [C@@]4 (CC) C5=C (C (=O) N6C (=C5) C=7C (C6) =CC=8C (N7) =CC=CC8) COC4=O
Molecular Formula
C45H49N7O11S
Molecular Weight
895.98
Storage Conditions
-20°C
Notes
For research use only.
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