R-130823
R-130823 is a potent and selective p38α MAPK inhibitor (IC50=22 nM) that suppresses pro-inflammatory cytokine release in vitro. It demonstrates significant in vivo efficacy by reducing established paw swelling and hyperalgesia in a rat adjuvant-induced arthritis model.
Product Specifications
CAS Number
321344-32-5
Smiles
C (CC1=CC=CC=C1) N2CCC (C=3C (=C (NC3) C4=CC=C (F) C=C4) C=5C=CN=CC5) =CC2
Molecular Formula
C28H26FN3
Molecular Weight
423.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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