DBPR112 HCl
DBPR112 is a clinical candidate EGFR inhibitor with potent activity against resistant mutations, including L858R/T790M and exon 20 insertions, outperforming osimertinib in vitro. It demonstrates favorable oral pharmacokinetics, significant in vivo antitumor efficacy in xenograft models, and a promising safety profile for non-small cell lung cancer research.
Product Specifications
CAS Number
2889316-21-4
Smiles
N ([C@H] (CO) C1=CC=CC=C1) C2=C3C (=C (OC3=NC=N2) C4=CC=CC=C4) C5=CC (NC (/C=C/CN (C) C) =O) =CC=C5.Cl
Molecular Formula
C32H32ClN5O3
Molecular Weight
570.08
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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