(1S,9R) -Exatecan (mesylate)

(1S,9R) -Exatecan mesylate ((1S,9R) -DX8951f) is an isomer of Exatecan mesylate (HY-13631A) . Exatecan mesylate (DX8951f) is an inhibitor of DNA topoisomerase I with an IC50 of 2.2 μM (0.975 μg/mL) and can be used in cancer research[1].

Product Specifications

CAS Number

[2938875-54-6]

Product Name Alternative

(1S,9R) -DX8951f

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1s-9r-exatecan-mesylate.html

Concentration

10mM

Purity

98.48

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C)(O)=O.O=C1[C@@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O

Molecular Formula

C25H26FN3O7S

Molecular Weight

531.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.