Olanzapine/Samidorphan

Olanzapine/Samidorphan is an investigational combination therapy designed to deliver the antipsychotic efficacy of olanzapine for schizophrenia and bipolar I disorder while counteracting olanzapine-induced weight gain through opioid receptor blockade. This single-tablet formulation is a subject of research in preclinical and clinical studies exploring metabolic side effect mitigation.