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Antihistamine-1

Antihistamine-1 is a potent H1-antihistamine (Ki = 6.9 nM) with moderate blood-brain barrier permeability. It also inhibits the CYP2D6 enzyme and the hERG potassium channel (IC50 values of 5.4 and 0.8 μM, respectively) . This profile makes it a useful pharmacological tool for studying allergy, cardiotoxicity, and drug metabolism in both cellular and animal models.

Product Specifications

CAS Number

1186430-60-3

Product Name Alternative

CYP2D6, Antihistamine 1, Antihistamine1, Antihistamine-1

Field of Research

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Purity

99.69% (May vary between batches)

Solubility

DMSO:11 mg/mL (28.24 mM)

Smiles

C (N1C (=NC=2C1=CC=CC2) N3CCC (CC3) N4C=C (C) C=N4) C5=CC=C (F) C=C5

Molecular Formula

C23H24FN5

Molecular Weight

389.47

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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