Antihistamine-1
Antihistamine-1 is a potent H1-antihistamine (Ki = 6.9 nM) with moderate blood-brain barrier permeability. It also inhibits the CYP2D6 enzyme and the hERG potassium channel (IC50 values of 5.4 and 0.8 μM, respectively) . This profile makes it a useful pharmacological tool for studying allergy, cardiotoxicity, and drug metabolism in both cellular and animal models.
Product Specifications
CAS Number
1186430-60-3
Product Name Alternative
CYP2D6, Antihistamine 1, Antihistamine1, Antihistamine-1
Field of Research
Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery
Purity
99.69% (May vary between batches)
Solubility
DMSO:11 mg/mL (28.24 mM)
Smiles
C (N1C (=NC=2C1=CC=CC2) N3CCC (CC3) N4C=C (C) C=N4) C5=CC=C (F) C=C5
Molecular Formula
C23H24FN5
Molecular Weight
389.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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