BAY-678
BAY-678 is a potent, selective, and orally bioavailable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. Recommended as a chemical probe by the SGC, it is a valuable tool for investigating HNE's role in inflammatory and pulmonary diseases in both in vitro and in vivo research contexts.
Product Specifications
CAS Number
675103-36-3
Product Name Alternative
BAY 678, BAY678, BAY-678, HNE
Field of Research
Protein Biochemistry
Purity
97.89% (May vary between batches)
Solubility
Ethanol:4.3 mg/mL (10.74 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.24 mM) ; DMSO:90 mg/mL (224.8 mM)
Smiles
CC (=O) C1=C (C) N (C (=O) N[C@@H]1c1ccc (nc1) C#N) c1cccc (c1) C (F) (F) F
Molecular Formula
C20H15F3N4O2
Molecular Weight
400.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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