Cot inhibitor-2
This orally active small molecule is a potent and selective inhibitor of Cot (Tpl2/MAP3K8) with an IC50 of 1.6 nM. It effectively suppresses LPS-induced TNF-α production in human whole blood (IC50 = 0.3 μM), making it a valuable tool for investigating inflammatory signaling pathways in both cellular and animal models.
Product Specifications
CAS Number
915363-56-3
Product Name Alternative
Cot inhibitor 2, Cot inhibitor2, Cot inhibitor-2, COT/Tpl2, MAP3K, TNF-α
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.87% (May vary between batches)
Solubility
DMSO:40 mg/mL (74.15 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.63 mM)
Smiles
CCN1CCC (CC1) n1cc (CNc2cc (Cl) c3ncc (C#N) c (Nc4ccc (F) c (Cl) c4) c3c2) nn1
Molecular Formula
C26H25Cl2FN8
Molecular Weight
539.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Goat SH2 Domain-Containing Protein 3C (SH2D3C) ELISA Kit
Transforming Growth Factor Beta 1 (TGFb1) Magnetic Luminex Assay Kit