EB-47
EB-47 is a potent and selective PARP-1/ARTD-1 inhibitor (IC50 = 45 nM) that acts as an NAD+ mimetic, spanning both the nicotinamide and adenosine subsites. It is a valuable chemical probe for studying PARP-1 function in DNA repair and cellular signaling pathways in both in vitro and in vivo research contexts.
Product Specifications
CAS Number
366454-36-6
Product Name Alternative
EB 47, EB47, EB-47, ARTD1/PARP1, ARTD-1, PARP1
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
99.81% (May vary between batches)
Solubility
DMSO:60 mg/mL (111.62 mM) ; H2O:100 mg/mL (186.04 mM)
Smiles
O[C@H]1[C@H] (N2C=3C (N=C2) =C (N) N=CN3) O[C@H] (C (=O) N4CCN (CC (NC5=C6C (C (=O) NC6) =CC=C5) =O) CC4) [C@H]1O
Molecular Formula
C24H27N9O6
Molecular Weight
537.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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036305-PE 200 µL
GRIN3B, CT (GRIN3B, Glutamate [NMDA] receptor subunit 3B, N-methyl-D-aspartate receptor subtype 3B) (PE) discontinued
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