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Estradiol 3-sulfamate

Estradiol 3-sulfamate (BLE 00084) is a potent, orally bioavailable inhibitor of estrone sulfatase (ES), exhibiting a K (i) of 73 nM in human placental microsomes. Its application is primarily in breast cancer research, where it is used to study ES inhibition in both in vitro enzymatic assays and in vivo models of hormone-dependent tumors.

Product Specifications

CAS Number

172377-52-5

Product Name Alternative

E2MATE, BLE 00084, BLE00084, BLE-00084, Estrogen Receptor, estrogen receptor, estrone sulfatase, EstrogenReceptor, ES-J 995, ES-J995, ES-J-995, Estradiol 3 sulfamate, Estradiol 3sulfamate, Estradiol 3-sulfamate, ERR

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Purity

96.68% (May vary between batches)

Solubility

DMSO:50 mg/mL (142.26 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.69 mM)

Smiles

[H][C@@]12CC[C@H] (O) [C@@]1 (C) CC[C@]1 ([H]) c3ccc (OS (N) (=O) =O) cc3CC[C@@]21[H]

Molecular Formula

C18H25NO4S

Molecular Weight

351.46

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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