ML334
ML334 (LH601A) is a potent small-molecule NRF2 activator that disrupts the Keap1-NRF2 interaction. It has been shown to reduce cardiac fibroblast activation and proliferation in vitro, and to ameliorate cardiac fibrosis in preclinical models of myocardial infarction, highlighting its utility in cardiovascular disease research.
Product Specifications
CAS Number
1432500-66-7
Product Name Alternative
ML 334, ML334, ML-334, KEAP1-Nrf2, LH601A
Field of Research
Immunology & Inflammation, Metabolism Research
Purity
98.06% (May vary between batches)
Solubility
DMSO:30 mg/mL (67.19 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.2 mM) ; Ethanol:30 mg/mL (67.19 mM)
Smiles
OC (=O) [C@H]1CCCC[C@H]1C (=O) N1CCc2ccccc2[C@H]1CN1C (=O) c2ccccc2C1=O
Molecular Formula
C26H26N2O5
Molecular Weight
446.49
Storage Conditions
-20°C
Notes
For research use only.
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