Chloramphenicol palmitate

Chloramphenicol palmitate is an orally active prodrug of Chloramphenicol (HY-B0239), obtained from the esterification reaction between the agent and Palmitic acid (HY-N0830) . Chloramphenicol palmitate is rapidly and completely hydrolyzed by intestinal esterase, releasing Chloramphenicol. Chloramphenicol is an orally effective broad-spectrum antibiotic[1][2][3][4][5].

Product Specifications

CAS Number

[530-43-8]

UNSPSC

12352005

Hazard Statement

H350

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/chloramphenicol-palmitate.html

Concentration

10mM

Purity

98.25

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCCCC(OC[C@@H](NC(C(Cl)Cl)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)=O

Molecular Formula

C27H42Cl2N2O6

Molecular Weight

561.54

Precautions

H350

References & Citations

[1]Siti Nani Nurbaeti, et al. Sustained-release Microparticle Dry Powders of Chloramphenicol Palmitate or Thiamphenicol Palmitate Prodrugs for Lung Delivery as Aerosols.Eur J Pharm Sci. 2019 Oct 1;138:105028.|[2]Ambrose PJ. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984 May-Jun;9 (3) :222-38. |[3]Gassner B, et al. Pharmacokinetic and toxicological aspects of the medication of beef-type calves with an oral formulation of chloramphenicol palmitate. J Vet Pharmacol Ther. 1994 Aug;17 (4) :279-83. |[4]Dhingra A K, et al. Promoiety: A versatile tool for improving drug acceptability. Innovations in Pharmaceuticals and Pharmacotherapy, 2019, 7: 1-6. |[5]Wang R, et al. Substrate imprinted lipase nanogel for one-step synthesis of chloramphenicol palmitate. Green Chemistry, 2013, 15 (5) : 1155-1158.