Monomethyl auristatin E intermediate-3

Monomethyl auristatin E intermediate-3 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162) . Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) [1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Intermediate; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-3.html

Purity

97.26

Solubility

10 mM in DMSO

Smiles

CCC(C)C(C(O)=O)NC(OCC1=CC=CC=C1)=O

Molecular Formula

C14H19NO4

Molecular Weight

265.30

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.