GNE-5729
GNE-5729 is an orally bioavailable, brain-penetrant positive allosteric modulator of NMDARs, showing subunit selectivity with EC50 values of 37 nM (GluN2A), 4.7 μM (GluN2C), and 9.5 μM (GluN2D) . It is a valuable research tool for investigating NMDA receptor function in models of psychiatric and neurological disorders, supporting both in vitro and in vivo experimental applications.
Product Specifications
CAS Number
2026635-66-3
Product Name Alternative
GluN2D, GluN2C, GluN2A, GNE 5729, GNE5729, GNE-5729
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.40% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.71 mM) ; DMSO:80 mg/mL (186.83 mM)
Smiles
ClC1=C (N2C (=NC (CN3N=C (C (F) (F) F) C=C3Cl) =CC2=O) C=C1) [C@H]4[C@H] (C#N) C4
Molecular Formula
C17H10Cl2F3N5O
Molecular Weight
428.2
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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